Intraepithelial carcinoma (Bowen disease) - 上皮内癌（Bowen 病）
典型病例 ― 上皮内癌（Bowen 病） (Intraepithelial carcinoma (Bowen disease)) 可能被误诊为持久、不痒的湿疹。
relevance score : -100.0%
ReferencesBowen's disease (BD) 是一种起始于皮肤表皮的皮肤癌。它在白种人中更常见，通常出现在日晒部位，但也可能出现在其他部位。BD 通常表现为单个病变，并被视为更严重皮肤癌的前兆。为了确诊，医生通常依赖显微镜下检查组织样本（活检）。
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease(鲍文氏病)主要影响60岁以上的白人。主要危险因素包括长期日晒、免疫系统减弱、砷暴露和皮肤HPV感染。HPV 16、18、34和48株与生殖器部位的Bowen's disease(鲍文氏病)有关。HPV在非生殖器病例中的参与尚不清楚。
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
临床上常表现为身体任何部位的红斑、鳞屑或硬化区，最常见于小腿。
可通过多种治疗方案治愈，如冷冻疗法、刮除术、烧灼术、光动力疗法或病灶切除术。
○ 诊断和治疗
#Dermoscopy
#Skin biopsy
#Mohs surgery
#Photodynamic therapy